Coronavirus

[lamb22]

Here's the journalistic evidence that Pfizer has done in vitro and in vivo trials of their new drug.

View attachment 14055

COVID-19: New oral antiviral from Pfizer looks hopeful

Pfizer has recently published a paper demonstrating that its candidate antiviral drug is safe and has antiviral effects against SARS-CoV-2.

www.medicalnewstoday.com

Helpfully, the article also links to Pfizer's publically available paper. Published in Science, only one of the most famous journals in the world.

View attachment 14056

Science | AAAS

www.science.org

I'm a rank amateur and using Google I found this in 5 minutes. Dr John is either extremely poor at what he claims to be able to do or he's a liar.

Thanks Ant. Seems to be kosher. I do note that it is a pre print and presumably not peer reviewed or formally published yet. That might be his point. I might have verballed John so I'll go back and check the tape. If I have I'll wear the blame completely

 

[lamb22]

I did verbal John. He was talking about the binding mechanism of the molecule which was generated via computer model. Mea culpa mea maxima culpa.

Here is his commentary and the link to the research article.

"The crystal structure of 3CLpro in complex with PF-07321332, lopinavir, and ritonavir is not yet available. Therefore, the docked complex of PF-07321332, lopinavir, and ritonavir with 3CLpro was generated using the Molecular operating environment (MOE) software."

Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations - PubMed

The novel coronavirus disease, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), rapidly spreading around the world, poses a major threat to the global public health. Herein, we demonstrated the binding mechanism of PF-07321332, α-ketoamide, lopinavir, and ritonavir to the...

pubmed.ncbi.nlm.nih.gov

 

[AngryAnt]

Thanks Ant. Seems to be kosher. I do note that it is a pre print and presumably not peer reviewed or formally published yet. That might be his point. I might have verballed John so I'll go back and check the tape. If I have I'll wear the blame completely

Nah, I'll let you off the hook and him too. I tried to skip through the vid to find where he talks about the in silica stuff but couldn't find it.

 

[AngryAnt]

I did verbal John. He was talking about the binding mechanism of the molecule which was generated via computer model. Mea culpa mea maxima culpa.

Here is his commentary and the link to the research article.

"The crystal structure of 3CLpro in complex with PF-07321332, lopinavir, and ritonavir is not yet available. Therefore, the docked complex of PF-07321332, lopinavir, and ritonavir with 3CLpro was generated using the Molecular operating environment (MOE) software."

Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations - PubMed

The novel coronavirus disease, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), rapidly spreading around the world, poses a major threat to the global public health. Herein, we demonstrated the binding mechanism of PF-07321332, α-ketoamide, lopinavir, and ritonavir to the...

pubmed.ncbi.nlm.nih.gov

It's all good - interesting topic anyway.

 

[lamb22]

One of the World's leading critical care specialists is taking his hospital to Court for preventing him treating COVID patients with medications they deem unsuitable. Could be an interesting case.

https://covid19criticalcare.com/wp-content/uploads/2021/11/Dr.-P.-Marik-v.-Sentara-Healthcare.pdf

 

[RoarEmotion]

Lucky they don't prey on lack of english skills. Sorry cheap shot, just kidding.

I don't know what post or statement you are railing about. Is it this one?

"Interestingly though when you look at India and acknowledging the above confounders the provinces that have/had mandated Ivermectin like Goa, Uttar Pradesh and Delhi have less cases and deaths per head than the national average."

if it is, I am confused as it explicitly acknowledges other variables which might affect the outcome. Also it is a statement with no specific conclusion.

Cheers

Yea it’s that one because this type of statement is what gets used as a headline to promote vaccine hesitancy against folks who don’t understand math. I follow Malone on Twitter and the amount of headlines like this he shares is amazing.

You are linking mandating IVM and less deaths by putting them in the same sentence and now say it’s basically nothing. To what purpose would you do this?

If it was to bait folks in this thread then you got a bite from me and well played.

If it’s a statement with no specific conclusion then why bring it up in that manner?
What is the point you are trying to make?

We shouldn’t be talking about IVM correlation anymore, just scientifically conducted tests.

My grammar is sloppy, but it this type of careless language or more probably carefully selected careless language that is killing people.

 

[Tigers of Old]

Angry minority protesting again..Meanwhile the state is not far off 90% double vaxxed.

 

[TigerMasochist]

Angry minority protesting again..Meanwhile the state is not far off 90% double vaxxed.

Which protest was this? Anti vaxxers or anti dictator Dan's new excessive power grab?

 

[AngryAnt]

Which protest was this? Anti vaxxers or anti dictator Dan's new excessive power grab?

Both.

The shitty prop nooses were a classy touch

 

[AngryAnt]

Yeah no anti-vaxxers at all

 

[Scoop]

A couple of things on the protests. We are getting vaccinated at an astonishing rate. The people yesterday don't represent the mainstream views. And like any issue there is a lunatic fringe. The nooses are way over the top. QAnnon stuff is loopy and slightly deranged, Copy cat Jan 6 stuff. They have the right to be out there spouting incorrect crazy theories. It was peaceful in protest but not in some of the messages. I don't see it as the threat that is being portrayed as.

Arguing against the pandemic bill isn't unreasonable. It's the Trump, QAnnon and anti vaxxers that make the argument look loopy.

 

[caesar]

A couple of things on the protests. We are getting vaccinated at an astonishing rate. The people yesterday don't represent the mainstream views. And like any issue there is a lunatic fringe. The nooses are way over the top. QAnnon stuff is loopy and slightly deranged, Copy cat Jan 6 stuff. They have the right to be out there spouting incorrect crazy theories. It was peaceful in protest but not in some of the messages. I don't see it as the threat that is being portrayed as.

Arguing against the pandemic bill isn't unreasonable. It's the Trump, QAnnon and anti vaxxers that make the argument look loopy.

When you have these two pollies addressing the crowd I think it pretty much says it all

Victorian Liberal MP Bernie Finn and federal MP Craig Kelly both addressed the crowd on Saturday.

 

[IanG]

QAnnon stuff is loopy and slightly deranged,

Only slightly?

I don't see it as the threat that is being portrayed as.

Given the attempted US insurrection and the killing of UK politicians I think it has to be taken seriously as a threat.

 

[Scoop]

Only slightly?



Given the attempted US insurrection and the killing of UK politicians I think it has to be taken seriously as a threat.

LOL very deranged I was being kind.

In the US and the UK, it was already a majority force via Trump.

The lunatic fringe has always been a threat.

 

[CarnTheTiges]

LOL very deranged I was being kind.

In the US and the UK, it was already a majority force via Trump.

The lunatic fringe has always been a threat.

Yeah, when I read only slightly I recall the recent gathering to witness the unveiling of JFK Jr (according to them he faked his death, and was re-emerging to run alongside Trump for the 2022 election), and there was also a few of them who expected JFK to also reveal that he too was still alive and backing Donny. Quite apart from the fact that JFK, if he hadn’t been assassinated in ‘63 would now be over 100 years old, and how would either he or his son be able to hide from the public eye for so long, the Kennedy family are Democrats, not Republicans. Yet a whole bunch of these loons fell for it.

 

[lamb22]

Yea it’s that one because this type of statement is what gets used as a headline to promote vaccine hesitancy against folks who don’t understand math. I follow Malone on Twitter and the amount of headlines like this he shares is amazing.

You are linking mandating IVM and less deaths by putting them in the same sentence and now say it’s basically nothing. To what purpose would you do this?

If it was to bait folks in this thread then you got a bite from me and well played.

If it’s a statement with no specific conclusion then why bring it up in that manner?
What is the point you are trying to make?

We shouldn’t be talking about IVM correlation anymore, just scientifically conducted tests.

My grammar is sloppy, but it this type of careless language or more probably carefully selected careless language that is killing people.

Sorry Roar, but if your comprehension is poor it's not my fault or problem. Your view of the world is so dangerous and its why we have this modern inclination towards censorship. We're not allowed to talk about things because someone may get upset or misconstrue the message, Give me a *smile* break.

I've often shown the charts on Uttar Pradesh and Indonesia not to demonstrate correlation but to disprove a COVID myth. One that says you cant have low case numbers without high vaccination rates. In fact we are fed that myth on a daily basis by the media. You can in fact have low covid cases per head of population with lower vaccination rates. That is actually a demonstrable fact and If you have a problem with truth because it might encourage anti vaxxers and want to quash it you have a very dangerous philosophy indeed.

Here's some more uncomfortable facts for you.

Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States

www.ncbi.nlm.nih.gov

 

[jb03]

A couple of things on the protests. We are getting vaccinated at an astonishing rate. The people yesterday don't represent the mainstream views. And like any issue there is a lunatic fringe. The nooses are way over the top. QAnnon stuff is loopy and slightly deranged, Copy cat Jan 6 stuff. They have the right to be out there spouting incorrect crazy theories. It was peaceful in protest but not in some of the messages. I don't see it as the threat that is being portrayed as.

Arguing against the pandemic bill isn't unreasonable. It's the Trump, QAnnon and anti vaxxers that make the argument look loopy.

I doubt anyone who attended yesterday's march has read the bill, or even understands it. Highlights the dangers of simply reading Herald Sun headlines.

 

[mrposhman]

Sorry Roar, but if your comprehension is poor it's not my fault or problem. Your view of the world is so dangerous and its why we have this modern inclination towards censorship. We're not allowed to talk about things because someone may get upset or misconstrue the message, Give me a *smile* break.

I've often shown the charts on Uttar Pradesh and Indonesia not to demonstrate correlation but to disprove a COVID myth. One that says you cant have low case numbers without high vaccination rates. In fact we are fed that myth on a daily basis by the media. You can in fact have low covid cases per head of population with lower vaccination rates. That is actually a demonstrable fact and If you have a problem with truth because it might encourage anti vaxxers and want to quash it you have a very dangerous philosophy indeed.

Here's some more uncomfortable facts for you.

Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States

www.ncbi.nlm.nih.gov

The problem is Lamby, is you spout those 2 countries but have no actual evidence of WHY they are so low. From memory Utter Pradesh was initially one of the states that was totally overrun by Covid, so potentially the low case numbers now are all due to natural immunity setting in rather than anything to do with Ivermectin but you continue to spout Ivermectin despite there being zero actual evidence (only anecdotal) that it "may" have had an impact.

You don't know and neither does anyone else why Utter Pradesh has low numbers, just most are willing to wait for actual evidence based conclusions to be made, whilst others (the minority) want to jump on any solution as a "miracle cure".

 

[tigerlove]

One of the World's leading critical care specialists is taking his hospital to Court for preventing him treating COVID patients with medications they deem unsuitable. Could be an interesting case.

https://covid19criticalcare.com/wp-content/uploads/2021/11/Dr.-P.-Marik-v.-Sentara-Healthcare.pdf

Someone suing someone in the US. How unusual. This Dr is a sceptic and his previous philosophy around treatment of sepsis was proven wrong. From the evidence I've read on Ivermectin I'd say he's wrong again but it's the courts he'll have to provide proof. I suspect he will fail.

 

[AngryAnt]

The problem is Lamby, is you spout those 2 countries but have no actual evidence of WHY they are so low. From memory Utter Pradesh was initially one of the states that was totally overrun by Covid, so potentially the low case numbers now are all due to natural immunity setting in rather than anything to do with Ivermectin but you continue to spout Ivermectin despite there being zero actual evidence (only anecdotal) that it "may" have had an impact.

You don't know and neither does anyone else why Utter Pradesh has low numbers, just most are willing to wait for actual evidence based conclusions to be made, whilst others (the minority) want to jump on any solution as a "miracle cure".

There is a lot of evidence through excess death numbers that the numbers of Covid deaths were under-reported an order of magnitude in Uttar Pradesh. Health Nerd on Twitter already did a full analysis of the numbers which showed it peaked and was falling even before the so-called Ivermectin intervention, again probably due the disease already being endemic. Vaccination rates then consolidated these gains.

Lamb, I'm not sure I've seen anywhere that states that low cases rates must correlate with high vaccination rates. We saw that lockdowns in Australia pre-vaccine produced low case rates, at least prior to delta, so this seems like a strawman argument to me.